Eating disorders

1. Neurobiology of Anorexia Nervosa

Contact persons: Prof. Dr. S. Ehr­lich, Dipl.-Inf. D. Geis­ler, Dipl.-Psych. J. Zwipp, E. See­ger

Collaborators:

  • Prof. Dr. M. Smol­ka, Sys­te­mi­sche Neu­ro­wis­sen­schaf­ten, Dres­den;
  • Prof. Dr. U. Lehm­kuhl und Dr. R. Burg­hardt, Kli­nik für Psych­ia­trie, Psy­cho­so­ma­tik und Psy­cho­the­ra­pie des Kin­des- und Ju­gend­al­ters der Cha­rité Uni­ver­si­täts­me­di­zin Ber­lin

 

Anorexia Nervosa (AN) is one of the most common mental diseases in girls and young women. AN leads to severe medical complications and an increased mortality rate. Due to interruptions of somatic and psychological development processes in the course of this disease, the patients often suffer from long lasting negative consequences.

Previous studies in human subjects and animals have shown alterations in several neurotransmitter systems and neuropeptides, possibly induced by undernourishment and underweight. There is still little knowledge about the biological mechanism that promote the occurrence of this disease. One possibility to distinct “state”-markers (caused by underweight) from the more solid “trait” markers is the examination of patients with AN in different stages of the disease (e.g. acute phase, symptomatic phase and after successful treatment).

In close collaboration with the Department for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy at University Hospital Charité Berlin our group is researching disorders in the serotonergic system, of appetite regulating peptides and neurotrophic proteins as well as genetic associations. Additionally, neural correlates of important AN-involved psychological processes will be analyzed by magnetic resonance imaging methods. In this context we are especially interested in processes of reward, learning, cognitive control and regulation of emotions.

Please find more information at our Translational Developmental Neuroscience Lab (TransDeNLab).