Executive functions in microcephaly and in neuronal migration disorders

Research question

This study examines in how far executive functions are affected in patients with serious disorders of cortical development (microcephaly and neuronal migration disorders). Executive functions are basal functions of the brain, enabling to control the behavior in relation to the environment, as for example decision making, motor control, or error monitoring. In this study, children and adolescents with developmental disorders are compared to children and adolescents without developmental disorders (i.e. control group). Besides generating new insights about the involved cortical processes and the extent of impairments, this study could generate a new approach for an improved therapy.

Procedure

For this study different pc-based tasks, of about 10 to 20 minutes, are executed. Via screen, or headphones stimuli (i.e. words, symbols or tones), requiring a button press response are presented. Simultaneously the electric activity of the brain is measured by recording the fluctuation of the electric currents on the scalp, by means of an electroencephalogram (EEG). This procedure is painless and completely safe for children and adults.

Additionally, an IQ-test is conducted and some information about the course of pregnancy is acquired via a parent questionnaire. The testing is scheduled for 2-3 hours.

Potential candidates

  • Children and adolescents from 10 to 17 years without developmental disorders
  • Children and adolescents from 10 to 17 years with microcephaly, or neuronal migration disorder (only if the diagnostics have been run in the Neuropediatrics Unit of the university hospital Dresden Carl Gustav Carus)

Contact

If you want to take part in our study don’t hesitate to contact us via  E-mail to KJPForschung@uniklinikum-dresden.de or call us 0351-458 71 68.

To thank you for your assistance a suitable allowance will be given.

We would highly appreciate your participation in this study.