Tic & Obsessive-compulsive disorders

EMTICS (European Multicenter Tics in Children Studies)

The main focus of the European multicenter study is to explore the complex interaction between environment, autoimmunity and genetics in relation to the onset and clinical course of tic disorders and associated obsessive-compulsive symptoms.  We aim to identify the role of exposure to specific environmental factors, including psychosocial stress as well as a Streptococcal Infection on the onset of tics in a high-risk group of children. To investigate the relationship between GAS exposure and tic disorders, anti-streptococcal antibody pattern profiles are assessed in relation to manifestation and course of the tic disorder.

An extension of the study is the placebo-controlled trial of the efficacy of amoxicilline/clavulanic acid. It aims to analyze if the treatment with antibiotics in patients colonized by Group A Streptococcus (GAS) has an impact on the severity and frequency of tic symptoms.

We test both affected children and adolescents (3-16 years) and healthy siblings or offspring (3-10 years) of tic-patients. The children are accompanied alternating by telephone interviews and visits in the University hospital Dresden. At the visits on site a short interview, the completion of questionnaires, a blood draw and the donation of a throat swab and a hair sample are carried out. For algesic patients we use a patch that stops the sensation of pain at the puncture for a few minutes.

Contact: M. Sc. Psych. Benjamin Bodmer

Research Group: AG Rößner

For further information click here: EMTICS-Kurzinfo.pdf (German)

 

Tic-Treatment

In the treatment of tics, both pharmacological and behavioral therapeutic approaches are successfully applied. For both forms of intervention evaluation studies with positive results exist. However direct comparative data showing whether and to what extent a pharmacological intervention with tiapride is preferable to the behavioral intervention by Habit reversal training in terms of their short- and long -term efficacy and safety, or vice versa . The aim of the proposed study is therefore to investigate the short-term effects of both forms of therapy for the first time comparatively.

In this study, both affected and healthy children aged 10 to 17 years are examined. In affected individuals, the indication for treatment of their tic disorder should be provided and the choice of therapy is left to the study participants and their parents. The study comprises two EEG dates at intervals of 10 weeks (before and 10 weeks after the successful Tiaprid- or Habit reversal therapy ).

Contact: M. Sc. Psych. Benjamin Bodmer

Research Group: AG Rößner

 

TicGenetics

The aim of this international study is to detect genetic factors that can cause tic disorders and other related psychiatric disorders in certain people. Therefore we want to examine families. It is important that affected (from 3 years of age) as well as healthy family members take part in the study.

Initially during a detailed telephone interview, a  family tree is generated and the number of affected family members is identified. After that you will receive questionnaires to fill out at home. Afterwards an appointment in the University hospital in Dresden will take place. There the questionnaires will be reviewed and blood samples will be taken for the following analysis of genetic markers.      

Contact: M. Sc. Psych. Benjamin Bodmer

Research Group: AG Rößner

For further information click here: Tic-Genetics Informationen.pdf (German)